Hydralazine (Apressin) selectively enhances arterial vessels, lowers blood pressure. In contrast, nitroglycerin sodium nitroprusside extends equally refreshingly arterial and venous-courts. In the expansion of blood vessels decreased arterial and venous pressure, heart-reduction reflexively become more frequent. The drug is used in refreshingly crises, acute left ventricular non-sufficiency, as well as for controlled hypotension during surgical operations. Blockers - prazosin (MINIPRESS), doxazosin, terazosin refreshingly interior for a systematic treatment of arterial hypertension. Simultaneously, ? blockers narrow the blood vessels (block ?2 adrenoceptor). Myotropic antihypertensives known substances, which turn out to be a direct relaxing effect on smooth muscle blood refreshingly while refreshingly dilate, blood, the pressure decreases. Therefore, when a single application radrenoblokatorov mean arterial pressure drops usually insignificantly (with isolated systolic hypertension, blood pressure may drop and after a single of the refreshingly of ? blockers). For drugs in this group include nitroglycerin and sodium nitroprusside. Excretion refreshingly thiocyanate slow (t1 / 2 for 3 days) and prolonged intravenous introduction of sodium nitroprusside Fluorescent Treponemal Antibody the cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, refreshingly convulsions. The drug is administered in hypertensive crises intravenously over 30 seconds. In this activity fosfolambana reduced. On the background of hyperpolarization difficult opening of voltage-Ca2 + channels, is disturbed of calcium-reduction of smooth muscle of the arteries - blood pressure decreases. Activators of the potassium channels are used mainly diazoxide (giperstat). N0 stimulates vascular smooth muscle guanylate cyclase, increased levels of cGMP, which activates protein kinase G. When action of Ca2 + ATPase Ca2 + ions transported from the cytoplasm to sarkoplazmati-crystal reticulum Ca2 + content in the cytoplasm decreases. Radrenoblokatorov side effects: bradycardia, heart failure, in particular, the difficulty of atrioventricular conduction reduction of HDL cholesterol in the blood plasma, increased bronchial tone and peripheral spherical vessels (less pronounced in ? 1 blockers), strengthening of hypoglycemic agents, decreased physical activity. a2 ? blockers - labetalol (trandat), carvedilol (dilatrend) reduce cardiac output (block radrenoreceptors) and reduce peripheral vascular tone (block aadrenoreceptors). Drugs administered orally for a systematic treatment hypertension. Decreases ingibiruyushee fosfolambana influence on Ca2 + ATPase of sarcoplasmic reticulum. However, if radrenoblokatory applied systematically, through a 1 -2 weeks vasoconstriction refreshingly replaced by its extension - blood pressure decreases. Myotropic mechanism of action has not been elucidated. Sodium nitroprusside - cyanide.
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